Protocol Comparison

Longevity Protocols

What the world's top longevity researchers actually do β€” compared side by side, with evidence ratings.

Bryan Johnson
$2,000+/mo

Bryan Johnson

Tech entrepreneur spending $2M+/year on his Blueprint protocol to reverse aging.

Caloric RestrictionSleep Optimization100+ SupplementsOrgan Monitoring
Peter Attia
$200–500/mo

Peter Attia

Physician focused on lifespan & healthspan through metabolic health and exercise.

Zone 2 CardioVO2 MaxStability TrainingCGM Tracking
Rhonda Patrick
$100–300/mo

Rhonda Patrick

Biomedical scientist advocating nutrient-dense diets, sauna, and cold exposure.

MicronutrientsSauna ProtocolSulforaphaneOmega-3s
David Sinclair
$200–400/mo

David Sinclair

Harvard geneticist researching epigenetic reprogramming and NAD+ biology.

NMNResveratrolFastingEpigenetic Testing
Dave Asprey
$300–600/mo

Dave Asprey

Bulletproof founder and biohacker focused on brain performance and fat loss.

Bulletproof CoffeeRed Light TherapyNootropicsSleep Hacking

Side-by-Side Comparison

Johnson
Attia
Patrick
Sinclair
Asprey
πŸ₯— Diet
Vegan, 1,977 cal/day
High protein, flexible
Nutrient-dense omnivore
Skips breakfast, plant-heavy
High-fat, low-carb
πŸƒ Exercise
Structured daily
Zone 2 + strength
Varied + sauna
HIIT + walking
Efficient + recovery
😴 Sleep
8:30pm strict
7–8h, tracked
7–8h natural
Variable
Oura-tracked
πŸ’Š Key Supp
Blueprint stack
Rapamycin (Rx)
Sulforaphane
NMN + Resveratrol
MCT + Nootropics
πŸ’° Cost
$2,000+/mo
$200–500/mo
$100–300/mo
$200–400/mo
$300–600/mo

What They All Agree On

πŸ‹οΈ

Exercise is #1

All agree regular exercise beats any supplement.

😴

Sleep matters hugely

Every protocol prioritizes 7–8+ hours of quality sleep.

πŸ₯¦

Whole foods first

Diet quality is foundational across all approaches.

πŸ§ͺ

Test, don't guess

Blood work and biomarkers guide personalization.

❄️

Stress hormesis

Cold, heat, or fasting β€” controlled stress builds resilience.

πŸ’Š

Targeted supplementation

Supplements fill gaps, not replace good habits.

Protocol Deep Dives